Progress in Medicinal Chemistry
Release on 2011-09-22 | by

[14] did find activity in the interesting compound 2'-aza/AMT (V.26), which they synthesized from diethyl ... Neither compound was an inhibitor of DHFR from pigeon liver, and in fact the 3'-isopropyl derivative (V.28) appeared to ...

Progress in Medicinal Chemistry
  • Author:
  • Publisher: Elsevier
  • ISBN: 0080862748
  • Category: Medical
  • Page: 585
  • View: 925

There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

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